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Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent.

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Safety was evaluated by clinical assessment including vital signs and laboratory analyses designed to determine the incidence of adverse events, opportunistic infections, cancer, and death throughout the study; the incidence of failure to achieve primary closure of the transplant surgical wound at 2 weeks; and the formation of lymphoceles requiring intervention within 6 months after transplantation.

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The robust correlation between AUC 24 and C min with LCP-Tacro demonstrates that current practice of therapeutic drug monitoring of C min as a measure of tacrolimus exposure can also be applied to LCP-Tacro.

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Keywords: CYP3A4, CYP3A5, tacrolimus, kidney transplantation.

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